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Press Release

Bexion Pharmaceuticals, Inc. Announces First Patient Dosed with BXQ-350 in the ASIST Clinical Study

January 11, 2023|

Study Aims to Assess Safety and Efficacy of BXQ-350 in Combination with Standard of Care for mCRC FOR IMMEDIATE RELEASE Covington, KY, January 10, 2022 Bexion Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company developing biologics for the treatment of cancer and neuropathy, announced today that the first adult patient has been dosed in the Phase 1b/2 Placebo Controlled, Double Blinded Study on the Efficacy and Safety of BXQ-350 in Combination with mFOLFOX7 [...]

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  • Cincinnati Enquirer logo

Cincinnati Enquirer: 8 Cincinnati biotech companies with big steps to watch in 2020

January 1, 2020|

Excerpt: Cincinnati has become a nurturing place for bright ideas in biotechnology, and 2020 could bring big advancements. The Cincinnati USA Regional Chamber of Commerce estimates the industry contributes more than $3 billion to the area economy. Nearly 800 locations employ more than 13,000 workers who are making average salaries of about $100,000 a year. In alphabetical order, here are eight Cincinnati biotechs aiming for milestones in 2020. Bexion Pharmaceuticals [...]

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Abstracts

Posters

Case Studies

Phase 1 Patient 1080-001:
Long Lasting Benefit in mCRC >5 years

PET/CT before BXQ-350

PET/CT after 18 months on BXQ-350

PET/CT before BXQ-350
PET/CT after 18 months on BXQ-350
  • 40-yr old female with stage 4 metastatic colorectal carcinoma
  • Diagnosed in Nov 2015, previously treated with surgery, chemotherapy and radiation (>3 lines)
  • Rapid progression (5 months) prior to starting BXQ-350
  • Target lesion (1.5 cm) remained unchanged per Recist
  • Still Stable Disease over 5 years on study

Phase 1 Patient 1008-701:
Long Lasting Benefit in GBM > 5 years!

Screening

Day 56

Day 56 screening
  • Red Arrows indicate the initial target lesion that decreased in size while on study
  • Blue Arrows indicate new area of enhancement
  • Note: Surgery in May, 2018 revealed significant treatment effect with only trace tumor cells present. As of September, 2019 patient continues on study having completed 3 years in the trial.

Case Data: Glioblastoma (GBM)

  • Axial T1-post contrast (Ax SE T1 POST FC) 1.5T MRI of the brain of a 64-yr old male patient with glioblastoma (GBM) treated with BXQ-350. GBM was first diagnosed in 2013 and previously treated with surgery, chemotherapy and radiation. Measurable lesion reduction over time is apparent in the anterior corpus callosum and frontal lobe, with those bordering the ventricle.

Phase 1 Patient 1075-213:
Partial Response in Glioblastoma (-74%)

Screening

Day 56

Day 56 screening
  • 65-yr old female with rGBM
  • GBM diagnosed in March 2017 (stage IV) previously treated with surgery, chemotherapy and radiation
  • Rapid progression (2M) prior to starting BXQ-350 in May 2018
  • 1 target lesion (L parietal) 1.4 cm at Screening down to 0.36 cm at Day 56 (-74%)
  • Progressed after 948 days on BXQ-350