The Lysosome is an Underexploited Cellular Orchestrator

The Lysosome is an Underexploited Cellular Orchestrator

Often called the “stomach of the cell”, lysosomes digest and recycle internal and external molecules, like waste minerals and cellular debris.

1955: Lysosome described by Christian de Duve, terming them “suicide bags” for their role in autophagy and apoptosis.

1974: de Duve awarded Nobel Prize for his pioneering work describing lysosomes

Subsequent research implicates lysosomes in multiple pathological conditions and should be evaluated for not just lysosomal storage diseases, but for cancer, neurodegeneration, infection and autoimmunity.

The lysosome is one of the most poorly understood cellular mechanisms. Its importance once believed to be limited to the break down of waste materials and cellular debris has expanded to include much broader, critical functions including their importance in maintaining homeostasis in the cell.

Research over the last several decades has supported targeting the lysosome to treat a broad spectrum of diseases including lysosomal storage diseases, cancer, neurodegeneration as well as performing a role in immune function with implications both for infectious diseases and autoimmune processes.

Lysosomes also involve the delivery of other biologicals and antibody drug conjugates. In addition, many drugs are found to accumulate inside lysosomes, allowing them to contribute to our understanding of pharmacokinetics, drug-drug interactions, and toxicity profiling.