Chemotherapy Induced Neuropathic Pain

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CIPN is a painful, debilitating condition that occurs when nerve cells of the peripheral nervous system are damaged or destroyed by chemotherapeutic agents.

CIPN is a common occurrence. Up to 90% of patients may suffer from CIPN during treatment and in nearly 50% of cases symptoms can persist  6 years after receiving chemotherapy treatment.3

Symptoms of CIPN

The most common side effects of CIPN include tingling (“pins and needles”), burning, numbness, shooting pain, throbbing, stabbing, or “buzzing” sensation.  Weakness in the area of the body affected is also a common side effect of CIPN.

In addition to sensory symptoms, CIPN can also impact critical bodily functions that affect walking, breathing, and blood pressure.4

Unfortunately, there are no FDA approved treatments for CIPN.  Off-label usage of anticonvulsants, antidepressants, opioids, and topical analgesics are employed to mask the pain but fail to address the underlying problem of CIPN.

CIPN is a substantial clinical problem, there is no good prevention of it except to not give the drug or to decrease the dose…

Charles L. Loprinzi, MD, FASCO, Regis Professor of Breast Cancer Research, Mayo Clinic, Rochester, Minnesota and ASCO Expert Panel Co-Chair; Medscape: April 12, 2017
References
  1. Kosko, K. CIPN Experienced by Many Patients Years After Treatment. Oncology Nursing News, Cranbury NJ: https://www.oncnursingnews.com/publications/oncology-nurse/2017/september-2017/cipn-experienced-by-many-patients-years-after-treatment. Accessed January 22, 2021
  2. Sampson S, D.O, Pietrangelo, A. What are the symptoms of CIPN ? https://www.healthline.com/health/cancer/neuropathy-from-chemo. Updated on January 24, 2019. Accessed January 22, 2021.
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