There is a significant physical, emotional, and financial impact associated with CIPN.

Neuropathic pain may have an even greater impact on patients than other chronic pain syndromes, with affected individuals characterizing their rating quality of life as “worse than death”.5 Patients with CIPN also have a 1.8 times greater risk of experiencing a fall. 6

Patient in pain

In addition to physical symptoms, studies demonstrate that CIPN can lead to psychological issues including anxiety, depression, and stress disorder.7 The economic burden of CIPN is also significant. Current estimates in the US alone is $52B equating to a $17,000 per patient increase in healthcare costs.6,7

  1. S. J. L. Flatters, P. M. Dougherty L. A. Colvin. Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review. British Journal of Anaesthesia, 119 (4): 737–49 (2017)
  2. Kerri M. Winters-Stone, et al. Falls, Functioning, and Disability Among Women With Persistent Symptoms of Chemotherapy-Induced Peripheral Neuropathy. J Clin Oncol. 2017 Aug 10; 35(23): 2604–2612.
  3. Poupon L, et al. Minimizing chemotherapy-induced peripheral neuropathy: Preclinical and clinical development of new perspectives. Expert Opinion on Drug Safety, Volume 14, 2015 – Issue 8
Neuroprotective Outcomes
Market Opportunity
What is CIPN?
Impact of CIPN